@article{calvanese_genesis_2023,

title = {The genesis of human hematopoietic stem cells},

author = {Vincenzo Calvanese and Hanna K. A. Mikkola},

url = {https://ashpublications.org/blood/article/142/6/519/496470/The-genesis-of-human-hematopoietic-stem-cells},

doi = {10.1182/blood.2022017934},

issn = {0006-4971, 1528-0020},

year  = {2023},

date = {2023-08-01},

urldate = {2025-09-18},

journal = {Blood},

volume = {142},

number = {6},

pages = {519–532},

abstract = {Abstract 

 Developmental hematopoiesis consists of multiple, partially overlapping hematopoietic waves that generate the differentiated blood cells required for embryonic development while establishing a pool of undifferentiated hematopoietic stem cells (HSCs) for postnatal life. This multilayered design in which active hematopoiesis migrates through diverse extra and intraembryonic tissues has made it difficult to define a roadmap for generating HSCs vs non–self-renewing progenitors, especially in humans. Recent single-cell studies have helped in identifying the rare human HSCs at stages when functional assays are unsuitable for distinguishing them from progenitors. This approach has made it possible to track the origin of human HSCs to the unique type of arterial endothelium in the aorta-gonad-mesonephros region and document novel benchmarks for HSC migration and maturation in the conceptus. These studies have delivered new insights into the intricate process of HSC generation and provided tools to inform the in vitro efforts to replicate the physiological developmental journey from pluripotent stem cells via distinct mesodermal and endothelial intermediates to HSCs.},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{calvanese_mapping_2022,

title = {Mapping human haematopoietic stem cells from haemogenic endothelium to birth},

author = {Vincenzo Calvanese and Sandra Capellera-Garcia and Feiyang Ma and Iman Fares and Simone Liebscher and Elizabeth S. Ng and Sophia Ekstrand and Júlia Aguadé-Gorgorió and Anastasia Vavilina and Diane Lefaudeux and Brian Nadel and Jacky Y. Li and Yanling Wang and Lydia K. Lee and Reza Ardehali and M. Luisa Iruela-Arispe and Matteo Pellegrini and Ed G. Stanley and Andrew G. Elefanty and Katja Schenke-Layland and Hanna K. A. Mikkola},

url = {https://www.nature.com/articles/s41586-022-04571-x},

doi = {10.1038/s41586-022-04571-x},

issn = {0028-0836, 1476-4687},

year  = {2022},

date = {2022-04-01},

urldate = {2025-09-18},

journal = {Nature},

volume = {604},

number = {7906},

pages = {534–540},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

@article{calvanese_mllt3_2019,

title = {MLLT3 governs human haematopoietic stem-cell self-renewal and engraftment},

author = {Vincenzo Calvanese and Andrew T. Nguyen and Timothy J. Bolan and Anastasia Vavilina and Trent Su and Lydia K. Lee and Yanling Wang and Fides D. Lay and Mattias Magnusson and Gay M. Crooks and Siavash K. Kurdistani and Hanna K. A. Mikkola},

url = {https://www.nature.com/articles/s41586-019-1790-2},

doi = {10.1038/s41586-019-1790-2},

issn = {0028-0836, 1476-4687},

year  = {2019},

date = {2019-12-01},

urldate = {2025-09-18},

journal = {Nature},

volume = {576},

number = {7786},

pages = {281–286},

keywords = {},

pubstate = {published},

tppubtype = {article}

}