We stay focused on translating our discoveries into action: designing new approaches for HSC-based therapies that are more potent, scalable, and clinically viable. At the same time, we flip the script on stemness: leveraging our insights to selectively dismantle this program in leukemia stem cells, aiming to break the cycle of resistance and relapse.
From Discovery to Therapy Read More »
Leukemia stem cells hijack normal stemness programs to resist treatment and fuel relapse. By decoding the rules of normal HSC biology, we aim to uncover their weak spots and shut them down.
Targeting Leukemia Stem Cells Read More »
We are breaking down the transcriptional and regulatory programs that define stemness. What makes a cell stay a stem cell? And how can we preserve that magic in a dish, when we try to make more of them, trickle them to perform better, or correct them to treat genetic defects?
Molecular Dissection of HSC Self-Renewal Read More »
We study how engraftable HSCs are born during embryonic development and how different niche environments shape their journey to functional maturity. Mr. embryo is the only one in the world able to make these cells: we need to learn from the Master if we want to come any closer to make functional HSC in a dish.
Developmental Origins of HSCs Read More »
